An operational RNA code for amino acids and possible relationship to genetic code.
نویسندگان
چکیده
منابع مشابه
An operational RNA code for amino acids and possible relationship to genetic code.
RNA helical oligonucleotides that recapitulate the acceptor stems of transfer RNAs, and that are devoid of the anticodon trinucleotides of the genetic code, are aminoacylated by aminoacyl tRNA synthetases. The specificity of aminoacylation is sequence dependent, and both specificity and efficiency are generally determined by only a few nucleotides proximal to the amino acid attachment site. Thi...
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It has been suggested that tRNA acceptor stems specify an operational RNA code for amino acids. In the last 20 years several attributes of the putative code have been elucidated for a small number of model organisms. To gain insight about the ensemble attributes of the code, we analyzed 4925 tRNA sequences from 102 bacterial and 21 archaeal species. Here, we used a classification and regression...
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A significant part of the genetic code likely originated via a chemical interaction, which should be experimentally verifiable. One possible verification relates bound amino acids (or perhaps their activated congeners) and ribonucleotide sequences within cognate RNA binding sites. To introduce this interaction, I first summarize how amino acids function as targets for RNA binding. Then the expe...
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The amino acid-trinucleotide relationships of the genetic code have long prompted interest in finding a historical rationale for why particular nucleotide triplets correspond to specific amino acids. Efforts to find stereochemical complementarity between a particular amino acid side chain and a specific triplet have been largely unsuccessful, as have been attempts to demonstrate specific amino ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1993
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.90.19.8763